Phospholipase a2 receptor antibody pla2r

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August undefined, 2024

WebAug 19, 2014 · Background The presence of antibodies against the M-type phospholipase A2 receptor (PLA2R-AB) is considered to be a promising serological diagnostic biomarker of idiopathic membranous nephropathy (iMN). However, controversy remains about the diagnostic accuracy of serum PLA2R-AB testing. Here, we performed a comprehensive … WebBackground: The presence of antibodies against phospholipase A2 receptor (PLA2R-Abs) in serum at diagnosis is reported to be related to the rate of spontaneous remission in patients with idiopathic membranous nephropathy (IMN); however, there is still lack of enough samples to illustrate this problem. Here, we conducted a comprehensive meta-analysis to …

Anti-Phospholipase A2 Receptor - Anti-PLA2R

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebJan 3, 2024 · Phospholipase A2 receptor (PLA2R) is the most common primary target antigen of idiopathic membranous nephropathy (MN) although PLA2R antibodies are also reported to be present in malignancy-associated MN. However, a case of PLA2R-positive MN secondary to PLA2R-positive carcinoma has not been reported. graphic print pants

Phospholipase A2 Receptor - an overview ScienceDirect …

WebMar 10, 2024 · The M-type phospholipase A2 receptor (PLA2R) has been identified as the main target antigen in the pathogenesis of iMN . Some evidence suggests that IgG4 anti-PLA2R antibodies can bind MBL to activate the lectin complement pathway . Based on this evidence, we hypothesized that MBL-initiated complement activation is involved in the … WebRecent clinical studies have revealed that circulating autoantibodies to the podocyte M-type receptor for secretory phospholipase A2 (PLA2R) can be measured in 70% to 80% of … WebPhospholipases A 2 include several unrelated protein families with common enzymatic activity. Two most notable families are secreted and cytosolic phospholipases A 2. Other families include Ca 2+ independent PLA2 (iPLA2) and lipoprotein-associated PLA2s (lp-PLA2), also known as platelet activating factor acetylhydrolase (PAF-AH). chiropractic elk grove

Serum anti-phospholipase A2 receptor (PLA2R) antibody detected …

Anti-phospholipase A2 receptor antibody in membranous nephropathy

WebHave a medical condition that can cause damage to the kidneys including cancer and lupus. Symptoms and Causes What causes membranous nephropathy (MN)? Most cases of MN are now known to be caused by an antibody to a protein on the podocyte called the phospholipase A2 receptor (PLA2R). WebPhospholipase A2 Receptor (PLA2R) Antibody, IgG with Reflex to Titer 2011828 Copy Utility Click to copy Test Number / Name Choose the Right Test ARUP Consult® assists with … chiropractice madison wi medicaidWebMar 14, 2024 · The discovery of antibodies against M-type phospholipase A2 receptor (PLA2R) situated on the cell surface of human podocytes has been a turning point for the MN field . Until recently, we lacked experimental evidence that PLA2R was indeed the culprit antigen that triggered the disease, mainly because it is not expressed on mouse podocytes. graphic print on metal

"WebOct 8, 2015 · PLA2R — Phospholipase A2 Receptor Antibodies, Serum View all test information details. 63036 — Phospholipase A2 Receptor (PLA2R) Immunofluorescent … " - Phospholipase a2 receptor antibody pla2r

Phospholipase a2 receptor antibody pla2r

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WebBackground: The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction. The effects of anti-PLA2R antibodies directly to the podocytes remain unclear. WebDec 19, 2011 · M-Type phospholipase A2 receptor (PLA2R) is a type I transmembrane protein abundantly expressed on glomerular podocytes. Antibodies against PLA2R were described by Beck et al ... Anti-phospholipase A2 receptor antibodies correlate with clinical status in idiopathic membranous nephropathy. Clin J Am Soc Nephrol. 2011; 6: 1286-1291.

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Web因此有学者提出，磷脂酶A2可评估IMN的临床疗效与预后。本文拟对此研究状况做以综述。一、PLA2R的结构. PLA2R属于甘露糖受体（Mannose Receptor，MR）家族，1989年由Stanescu等[5]首次对其做了报道。迄今为止，共发现了两个亚型的PLA2R——M型和N型[6]。 WebMay 24, 2024 · Anti-PLA2R antibodies are highly specific to primary MN, however anti-PLA2R antibodies have been identified in some secondary MN such as hepatitis B (HBV) and C (HCV), use of non-steroidal anti-inflammatory drugs, ... PLA2R: Phospholipase A2 receptor: SLE: Systemic lupus erythematosus:

WebPhospholipase A2 receptor (PLA2R) is present in normal podocytes and in immune deposits in patients with idiopathic membranous nephropathy, indicating that it is a major antigen … Web180 kDa secretory phospholipase A2 receptor antibody; C-type lectin domain family 13 member C antibody; CLEC13C antibody; M type receptor antibody; ... Ramachandran R et al. PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians.

WebPhospholipase A2 Receptor (PLA2R) Antibody Panel This test is used to differentiate primary membranous nephropathy from secondary membranous nephropathy, and …

WebAntibodies to the phospholipase A2 receptor (PLA2R) occur in 70% to 80% of patients. Less frequently (in up to 10%), antibodies against thrombospondin type-1 domain-containing …

WebRecent studies have shown that in approximately 70% of patients with primary MN (pMN), the immune complexes consist of autoantibodies against the podocyte protein M-type phospholipase A2 receptor (PLA2R).(1) There is also evidence that levels of anti-PLA2R autoantibodies correlate well with disease activity and progression.(2) The presence of ... graphic print one piece swimsuitWebMar 11, 2024 · Phospholipase A2 receptor (PLA2R)–associated membranous nephropathy (MN) with circulating serum autoantibodies to PLA2R (SAb+) but no deposits of PLA2R antigen in glomerular tissue by immunofluorescence (GAg−) has been reported. However, little is known about the clinicopathological characteristics or prognosis of this subtype of … chiropractic electric massage toolsWebThe discovery in 2009 of the M-type phospholipase A2 receptor (PLA2R) as the primary target in membranous nephropathy (MN) greatly advanced basic and clinical research. … chiropractic embroidery designsWebApr 11, 2024 · Approximately 80% of PMN cases arise due to autoantibodies that recognize the phospholipase A2 receptor (PLA2R) antigen expressed on podocytes. Anti-PLA2R is both a diagnostic and prognostic biomarker, and total aPLA2R antibody level has been shown to be a biomarker for prognosis of outcome in patients with PMN. chiropractic email marketingWebJun 15, 2024 · Materials and methods: An open-label prospective comparative study included 56 PMN patients (pts) with nephrotic syndrome (NS) and high serum level of antibodies to the phospholipase A2 receptor anti-PLA2R (mean age 5112 years, men 70%). We recorded demographic and clinical parameters at the time of kidney biopsy, data from … chiropractic employment agencyWebSep 21, 2024 · Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful for affirming the diagnosis of idiopathic membranous nephropathy (IMN). Time-resolved fluoroimmunoassay (TRFIA) is highly sensitive and ... chiropractic employment floridaWebAnti-phospholipase A2 receptor antibody levels at diagnosis predicts spontaneous remission of idiopathic membranous nephropathy. AU Jullien P, Seitz Polski B, Maillard N … chiropractic employment