Klf4 atherosclerosis

Author: vtpa

August undefined, 2024

WebNov 19, 2012 · Here, we show that endothelial KLF4 is an essential determinant of atherogenesis and thrombosis. Using in vivo EC-specific KLF4 overexpression and knockdown murine models, we found that KLF4 induced an antiadhesive, antithrombotic … WebAtherosclerosis, the leading cause of death, is a vascular disease of...

Krüppel-Like Factors : Crippling and Uncrippling ... - ScienceDirect

WebJan 11, 2024 · Notably, “Atherosclerosis Signaling” was the top pathway associated with the gene expression pattern in Klf4-deleted CD11b + myeloid cells isolated from Hi-Myc tumors. Atherosclerosis is a progressive disease that narrows the vascular lumen through a buildup of arterial plaque, an amalgam of lipids, macrophages and other leukocytes, smooth ... WebOct 11, 2012 · In summary, our observations implicate myeloid KLF4 as a key regulator of experimental atherogenesis in mice. The fact that KLF4 has been shown to confer favorable anti-inflammatory effects in both the … current buy america act

Role of Kruppel-like factor 4 in atherosclerosis - ScienceDirect

WebMay 18, 2015 · On the basis of in vivo KLF4 chromatin immunoprecipitation–sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many... WebNov 26, 2024 · In this mechanism induced by oxidized low-density lipoprotein (oxLDL), the KLF4 factor suppresses the expression of VSMC genes (SM22α, ACTA2, MYH11) by binding to the G/C repressor element in the gene promoter and by inhibiting the binding of transcription factors to the CArG element mechanism, leading to phenotypic switching ( … WebJul 17, 2024 · Taken together, our results suggest that most SMC phenotypes in advanced atherosclerotic lesions are conserved between humans and mice, and, taken with previous knowledge that SMC Klf4 is atheropromoting in mice and contains a human GWAS CAD … current buy buy baby offers

KLF4 alleviates cerebral vascular injury by ameliorating vascular ...

Smooth Muscle Cell Phenotypic Switch Induced by Traditional

WebOct 3, 2024 · Conclusions: KLF4 transactivates Ch25h and LXR, thereby promoting the synergistic effects between ECs and macrophages to protect against atherosclerosis susceptibility. Keywords: atherosclerosis; cholesterol; endothelial cells; inflammation; … WebDec 5, 2024 · Our study indicates that KLF4 mediates the link between glycolytic switch and VSMCs phenotypic transitions, suggesting that a previously unrecognized KLF4-eEF1A2/circCTDP1-PFKFB3 axis plays... current butterick pattern bookWebFeb 1, 2024 · Concordantly, cardiac-specific Klf4–/– mice develop heart dysfunction with aging or pressure overload associated with reduced ATP production, increased reactive oxygen species production, and mitochondrial dysfunction. current butcher hog prices

"WebIntroduction. Cardiovascular diseases (CVDs) are the most common causes of morbidity and mortality worldwide, which negatively affect public health. [] Endothelial damage is regarded as a key early event in the development of atherosclerosis, which contributes to the myocardial infarction. [] Human umbilical vein endothelial cells (ECs) are widely used … " - Klf4 atherosclerosis

Klf4 atherosclerosis

Frontiers Role of Vascular Smooth Muscle Cell Plasticity and ...

WebJul 1, 2024 · KLF4 is an important transcription factor of VSMCs phenotypic transformations, macrophage polarization, lymphocyte differentiation, and cell proliferation as atherosclerosis progression 29, 30,... WebAug 1, 2024 · However, since the clinical consequences of atherosclerosis typically occur well after our reproductive years, we sought to identify beneficial KLF4-dependent SMC functions that were likely to be evolutionarily conserved. We tested the hypothesis that …

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WebDec 1, 2014 · Blockade of mir-92a restores Klf2 and Klf4 expression, reduces endothelial inflammation and monocyte infiltration, thereby limiting atherosclerosis. 19 Disturbed flow and other proatherogenic factors also downregulate the endothelial expression of negative guidance cues, particularly Netrin-1 and Semaphorin3A, while upregulating EphrinB2, and … WebOn the basis of in vivo KLF4 chromatin immunoprecipitation-sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many that regulate pro-inflammatory responses of SMCs.

WebMar 29, 2024 · CSC increased the expression of inflammatory markers and reduced the contractile ones in both cell types, with KLF4 modulating the SMC phenotypic switch. Next, we performed a mass spectrometry-based differential proteomic approach on human SMCs and could show 11 proteins were significantly affected by exposition to CSC (FC ≥ 2.7, p ≤ … WebJun 29, 2024 · In macrophages, miR-34a regulated M1 and M2 macrophage polarization as well as cholesterol efflux via liver X receptor å (LXRå) and Kruppel-like factor 4 (KLF4). Consistent with these findings, macrophage-selective or global ablation of miR-34a markedly inhibited the development of atherosclerosis in Ldlr-/-mice or Apoe-/-mice. Finally ...

WebMay 24, 2024 · The KLF4 gene is itself a CAD GWAS risk allele with the putative variant (rs944172) located ≈265 kb upstream of the KLF4 transcription start site. The nature of this variant is unclear; however, it overlaps a weak AP1 binding site with some evidence for … WebMar 1, 2024 · Atherosclerosis is an important problem in modern medicine, the keys to understanding many aspects of which are still not available to clinicians. ... The large family of KLFs in humans includes 18 members, among which KLF2 and KLF4 are at the crossroads between endothelial cell mechanobiology and immunometabolism, which play …

WebApr 21, 2024 · Laminar, but not disturbed flow, induces expression of the extracellular matrix protein TN-X (tenascin-X) in mouse and human endothelial cells through the transcription factor KLF4 (Krüppel-like factor …

WebJan 1, 2024 · As a zinc finger domain-containing transcription factor, KLF4 involves in atherosclerosis development 27, 65. More importantly, it is reported that KLF4 is a critical regulator of macrophage polarization, and expression of KLF4 was robustly induced in M2 macrophages while markedly reduced in M1 macrophages 31. current buzzwords in educationWebJun 4, 2015 · KLF4 is also a crucial factor for the generation of induced pluripotent stem cells 9. It has also recently been shown that loss of Klf4 in endothelial cells (ECs) or myeloid cells results in... current buzz words 2021WebFurthermore, Klf4 has been identified as an anti-proliferative shear stress-responsive gene, and forced over-expression of Klf4 in VSMCs induces growth arrest. Klf4 may therefore be an important protective factor in disease states affected by shear stress, such as thrombosis, restenosis and atherosclerosis. current bzWebFeb 8, 2024 · KLF4 promotes phenotypic modulation into macrophage-like and Sca1-expressing mesenchymal-like VSMCs, while MSCs differentiate into VSMCs in vitro when exposed to TGFβ and PDGF-BB. VSMCs might also derive from ECs following EndMT driven by TGFβ signalling. current buzzwords 2023WebApr 7, 2024 · Background Although inflammatory cell adhesion molecules (CAMs) and anti-inflammation factor Kruppel-like transcription factor (KLF) 4 have all been reported to be induced after cerebral ischemic stroke (CIS), the close temporal and spatial relationship … current cabinet membersWebJul 1, 2024 · Nicotine injection with balloon overdilation induces atherosclerotic lesions by activating KLF4 expression. Atherosclerosis is a chronic inflammatory disease characterized by the narrowing of the ... current bwi temperatureWebFeb 2, 2016 · Atherosclerosis is a chronic progressive inflammatory disease and the leading cause of death worldwide 1-3 ... Similarly, the stem cell and induced pluripotent stem cell factor KLF4 has been shown previously to be required for phenotypic transition of cultured VSMCs in response to Platelet-derived growth factor ... current c8 wait times