Inhibitors of thiol-mediated uptake
Webb17 jan. 2024 · Diselenolane-mediated cytosolic delivery is non-toxic (MTT assay), sensitive to temperature but insensitive to inhibitors of endocytosis (chlorpromazine, methyl-β-cyclodextrin, wortmannin, cytochalasin B) and conventional thiol-mediated uptake (Ellman's reagent), and to serum. Webb3 maj 2024 · This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells enabled by oligochalcogenides or mimics, often disulfides, and …
Inhibitors of thiol-mediated uptake
Did you know?
WebbThiol-mediated uptake through endocytosis was explicitly considered as a mode of action, although inhibition was not reported. Such an inhibition with DTNB 1 was shown by … Webb25 mars 2024 · MβCD, an inhibitor of caveolae-mediated endocytosis, had no effect on NLCs-PEG 100-OH and thiolated NLCs but significantly increased the uptake of NLCs-PEG 10-OH. ... Thiol-Mediated Uptake. JACS Au, 1 (2024), pp. 710-728, 10.1021/jacsau.1c00128. View in Scopus. Leichner et al., 2024.
Webb17 jan. 2024 · Diselenolane-mediated cytosolic delivery is non-toxic (MTT assay), sensitive to temperature but insensitive to inhibitors of endocytosis (chlorpromazine, … Webb13 apr. 2024 · We performed endocytic inhibitor assay to investigate the uptake pathway(s) for the two topological isomers. Cells were pretreated with a given inhibitor before the incubation with SCPNs. After incubation, the free SCPNs were washed away, and cells were harvested for flow cytometry, inspecting the AF647 signal from the …
Webb14 apr. 2024 · In mice, the orally administered CoASH was found to have half-life of 69 ± 5 h (males) and 82 ± 6 h (females) in the liver, whereas in the brain it was 136 ± 14 h (males) and 144 ± 12 h (females). For acetyl-CoA, half-life was 71-74 and 117-158 h in the liver and brain, respectively. WebbHere we use fluorescent cyclic oligochalcogenides that enter cells by thiol -mediated uptake to systematically screen for more potent inhibitors, including …
Webb18 nov. 2024 · Europe PMC is an archive of life sciences journal literature.
Webbepidithiodiketopiperazines. Diselenolane-mediated cytosolic delivery is non-toxic (MTT assay), sensitive to temperature but insensitive to inhibitors of endocytosis (chlorpromazine, methyl-b-cyclodextrin, wortmannin, cytochalasin B) and conventional thiol-mediated uptake (Ellman's reagent), and to serum. i could take them memeWebb24 maj 2024 · ETP-mediated cellular uptake is more than 20 times more efficient compared to AspA, occurs without endosomal capture, depends on temperature, and is … i could tell synonymWebb18 nov. 2024 · Different activities found with different reporters reveal thiol-mediated uptake as a complex multitarget process. Preliminary results on the inhibition of the … i could talk to youWebbWell-known inhibitors of PDI include bacitracin and DTNB, which block the reductive functions of this enzyme and are often used as thiol blockers. 25,26 As shown in Figure 7, the cellular uptake of M-GGLG liposomes was reduced to 55%–83% of the control group’s by pretreatment with bacitracin or DTNB in HeLa, HCC1954, MDA-MB-468, and COS-7 … i could take your man if i want to songWebbThe inhibition of thiol-mediated uptake might contribute to activities of thiol-reactive antivirals such as 16, ETPs or ebselen, although they have been shown to bind to zinc fingers or inhibit proteases. 16,25,32–34 Finally, the inhibitors reported here could also … i could talk to you for hours lyricsWebb20 nov. 2024 · The thiol-mediated uptake of organic molecules similar to alcohols, ... Inhibitors of thiol-mediated uptake. Chemical Science, 2024; DOI: 10.1039/d0sc05447j; Cite This Page: MLA; APA; i could tell you had forgotten lyricsWebb23 nov. 2024 · The thiol-mediated uptake of organic molecules similar to alcohols, where oxygen is replaced by a sulphur atom, is one of the entry mechanisms, with its use by Human Immunodeficiency Virus (HIV) demonstrated a few years ago. No effective inhibitor is currently available because of the robustness of the chemical reactions and … i could tell you but then i would have to